crizotinib boosts levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction could possibly be desired for coadministered medicine which have been predominantly metabolized by CYP3A.
modafinil will increase the amount or influence of rabeprazole by affecting hepatic enzyme CYP2C19 metabolism. Insignificant/Importance Not known. Internet effect on pantoprazole actions mysterious because of opposing outcomes of CYP450 enzymes; monitor
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A handful of early animal experiments have noted that modafinil also partly activates the dopamine D2 receptor, and may advertise wakefulness by stimulating the discharge of dopamine throughout the brain (especially while in the nucleus accumbens) [twelve, 13].
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ketoconazole will increase the stage or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
tazemetostat will reduce the extent or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Outcome of coadministration of the twin CYP3A4 and CYP2C19 inhibitor with fedratinib has not been get more info researched.
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Belzutifan is a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors could boost incidence or severity of adverse results. Keep an eye on for anemia and hypoxia and cut down belzutifan dose as recommended.
In potential studies, system of modafinil will proceed for being examined since modafinil could generate doable abuse and dependancy and its waking system has not been totally elucidated [36,forty five].
Modafinil reportedly aided lessen the sleepiness induced by a genetic condition that causes the progressive reduction and weakening of muscles (
In Romania, modafinil is classed for a stimulant doping agent and is also prohibited in athletics competitions.
eslicarbazepine acetate will boost the degree or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check.